Proof of this concept was provided using mouse models wherein the locus that codes for Cdk4, one of the important gate-keepers of the mammalian cell cycle machinery, was targeted by genetic recombineering [36], [53].
In mouse models, wherein metastatic mammary carcinomas are induced by the doxycycline induction of Neu overexpression, withdrawal of the Neu oncogene by cessation of doxycycline therapy results in complete regression of the mammary tumours and its associated tumour metastases (Moody et al, 2002).
We chose to make use of the RIP1-Tag2 transgenic mouse model [ 18], wherein pancreatic islet carcinogenesis occurs secondary to the expression of the SV-40 large T-antigen (Tag) expression under the Rat Insulin Promoter (RIP).
In sepsis patients, extracellular ATP release in PMNs was elevated on days 0 1, corroborating our previous work in mouse sepsis models, wherein plasma ATP levels were elevated and contributed to PMN activation [7].
These data extend our previous observations in a mouse model of abdominal sepsis, wherein microarray-measured expression profiles from circulating leukocytes distinguished between infectious and non-infectious etiologies of systemic inflammation in a de-identified cohort [15].
To further expand on our initial observation that oxygen promotes genomic instability and tumorigenesis, we examined the effect of ambient oxygen on the APCMin/+ mouse model of intestinal neoplasia wherein the inactivation of the wild-type APC allele initiates the formation of polyps [34], [35].
Finally, in a recent report, suppression of breast cancer progression and metastasis was observed in a murine breast cancer model wherein mice lacked the IL-33 signaling receptor, ST2 [ 86], further supporting the role of the IL-33/ST2 axis in tumor formation and the progression of cancer.
Based on these assumptions, the present study was designed to evaluate the effect of olive extract in a mouse model of immunologically-induced fatigue, wherein purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigen were used as immunogens.
To evaluate whether EGFR is induced on neural stem cells, we used a mouse model of neonatal H/I wherein we could identify putative mouse stem cells using the LeX/SSEA-1 marker.
