Sentence examples for mouse model whereby from inspiring English sources

The oncogenic capacity of SYT-SSX2 was also demonstrated in a transgenic mouse model whereby SYT-SSX2, expressed in Myf5 lineage myoblasts, generated synovial sarcoma-like tumors with 100% penetrance [24].

Interestingly, several groups have observed the differential propensity of murine moncyte subsets to undergo apoptosis in a transgenic mouse model, whereby Gr1− monocytes fail to persist.

An example of this process was definitively shown in a mouse model, whereby alterations in TGF- β signalling in stromal fibroblasts produced forestomach neoplasms and PIN (Bhowmick et al, 2004).

The colon-26 mouse model, whereby the murine colon-26 cells are injected subcutaneously into the flank of mice, is commonly used to study the effects of several antitumor agents, including dietary agents 47– 51.

The role of MEF2C in postnatal muscle maintenance has been highlighted in a skeletal muscle specific Mef2c knockout mouse model, whereby sarcomeres appeared to be disorganized and fragmented [ 20].

On the basis of these findings, we propose a strategy for the HIS-CNS mouse model whereby mixed cultures of human fetal astrocytes and microglia will be transduced with lentiviral vectors that express green fluorescent protein before transplantation into the mouse brain.

We have now engineered two new mouse models whereby Tie2 expression is confined to either endothelial cells or keratinocytes.

Over the past 10 years, Dr. Tuohy and his team have therefore conducted research studies using three different mice models, whereby none of the mice injected with the vaccine developed any tumors at the end of the testing period.

We have generated a new mouse model of tauopathy whereby pan-neuronal overexpression of the most abundant WT adult brain isoform of human tau results in the early signs of tauopathy.

It will also be important to study the effects of MBD4tru at more physiological levels, for example, by creating a mouse knock-in model whereby a truncated Mbd4 allele is expressed under the control of the endogenous promoter.

The Aldh1b1tm1lacZ null mice provide a model whereby early defects in fetal and neonatal stages manifest later in islet functional defects and deterioration of glucose homeostasis, capturing aspects of type 2 diabetes patients.