The JNPL3 mouse model utilizes the mouse prion promoter [ 5] to drive mutant human tau expression [ 31].
Kim et al report their findings with a mouse model utilizing ovalbumin and Aspergillus protease to induce eosinophilic inflammation.
The study assessed the histological effects of perineural injections of propylene glycol and three medical gels in a mouse model utilizing ultrasound guided microinjection techniques.
As an alternative, a mouse model utilizing repeated doses of bleomycin has been proposed to more closely replicate pathological features of IPF in humans (Degryse et al., 2010).
In these studies, we generated a mouse model utilizing the Cre- loxP system to ablate CENP-F protein expression in a cardiomyocyte-specific manner (termed CENP-F −/− hereafter).
Besides the ability to detect and identify diseased state, the profile demonstrates the potential to monitor tumor response to chemotherapy in an orthotopic mouse model utilizing this miRNA profile.
These cellular defects are not strictly dependent on the individual hypomorphic MCM allele used, as a mouse model utilizing an MCM2IRES-CreERT2/IRES-CreERT2 allele, which resulted in a reduction in total protein level to roughly 1/3 the wild type amount, exhibited similar defects in dormant origin usage and genome instability [45,62].
This review highlights novel findings from a DMD mouse model utilizing systemic multiexon skipping targeting exons 45 55, discusses the major hurdles and limitations impeding the translation of this approach into clinical therapies along with the potential solutions, and provides a perspective on the future of clinical exon 45 55 skipping in DMD patients.
Notwithstanding differences in the mouse models utilized (Mecp2tm1Tam [24], Mecp21lox [25] or Mecp2tm1.1Bird [this report]), the enrichment paradigms (continuous from 4 weeks of age [24], continuous from 3 weeks of age [25] or transient from 3 to 5 weeks of age [this report]) and the methods used to test its effects, EE is capable of eliciting improvement in some RTT like phenotypes.
The experiments and the unique mouse models utilized in this study implicate the importance of targeting IL-17A for preventing metastasis associated with metastatic BC.
