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This mouse model therefore offers a platform to test strategies for the restoration of normal splicing.
Our mouse model therefore represents an excellent preclinical model to test novel intervention strategies for invasive and metastatic breast cancer.
The present mouse model therefore represents a novel genetic tool to identify pathways that are implicated in the pathophysiology of PM21.
We chose this mouse model therefore in order to compare CY with a wide range of traditional chemotherapeutics as well as targeted therapeutics in an in vivo setting.
The SRF-VP16 iHep mouse model therefore permits the study of molecular events associated with both initiation and progression of cancer.
The standard mouse model therefore examines the interaction between homogeneous cancer cells inoculated or transplanted into homogeneous mice that are in a single, very artificial, metabolic state.
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Mouse models therefore represent powerful tools to study mechanisms of leukaemogenesis.
Our mouse models therefore enabled us to study the absence of HDAC4 in a spatially and temporally selective fashion.
Lpcat3-deficient mouse models therefore provide an unprecedented opportunity to study the physiological and pathophysiological consequences of manipulation of membrane phospholipid composition in vivo.
The BALB/c mouse model can therefore be used to examine Trp53-dependent formation of mammary carcinoma.
These results eliminate the possibility of NMDAR mediated neuroplasticity in the different DA neuronal subpopulations in our NR1DATCre mouse model and therefore suggest that NMDARs on non-DA neurons within the VTA must play a major role in cocaine-related addictive behavior.
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