Sentence examples for mouse model targeted from inspiring English sources

However, thanks to a unique mouse model targeted for the ERα palmitoylation site membrane, we recently demonstrated a very contrasted involvement of MISS-mediated E2 action in two different tissues: the uterus in which the E2 response depends on ERα nuclear action and the arteries involving exclusively MISS of ERα to mediate E2 response (Abot et al, 2013; Adlanmerini et al, 2014).

There is a report to suggest HNF6 activity to be independent of FOXA2 [20] and in this conditional FOXA2 knockout mouse model targeted expression of HNF6 genes appeared to be independent of the presence of FOXA2.

This transgenic mouse model targets expression of truncated decorin to keratocytes, thereby mimicking the human frameshift mutation.

Here we describe a novel mouse model targeting these same genetic alterations to Pax3-expressing cells, which in the neonatal mouse pons consist of a Pax3 +/Nestin +/Sox2 + population lining the fourth ventricle and a Pax3 +/NeuN + parenchymal population.

Our Grp94 knockout mouse model targets exon 2 of the Grp94 allele.

In the mouse model, targeting recombinant antigen to the epidermis induced a typical TH2-biased immune response type.

This miRNA inhibited human tumor cell growth in vitro and in vivo xenograft mouse model targeting CCND1, ERBB2, DNMT3A, and DNMT3B [ 78].

In addition, Enomoto and coworkers recently reported on the investigation of an albumin-HDGF transgenic mouse model targeting HDGF-overexpression to hepatocytes [ 47].

In mouse models targeted disruption of retinoblastoma protein or retinoic acid receptor in the BM microenvironment results in the development of myeloproliferative disorders [ 16].

Despite the numerous reports using different genetically engineered mouse models targeting the ghelin system, its endogenous relevance in metabolism seems to be less important than its pharmaceutical options.

Here we report the creation of mouse models targeting exon 2 of the Grp94 allele that allow both traditional and conditional knockout (KO) of GRP94.