Although TTF-1 is amplified in primary human lung cancers, it inhibits primary lung tumors from metastasizing in a mouse model system.
Using a mouse model system, we demonstrate that anergic CD8+ T cells can persist and retain some functional capabilities in vivo, even after the induction of tolerance.
In the second report, Woods et al.14 claimed the first direct experimental evidence to suggest that the expression of IL2Rγ through a lentiviral vector affected the incidence of leukemias in a mouse model system.
Here we employ a pre-clinical mouse model system and show that resistance to ICB is directly mediated by the suppressive activity of infiltrating myeloid cells in various tumours.
We are using a plasmid-based lacZ transgenic mouse model system to rapidly measure, in a statistically reliable way, the mutagenic potential of charged particle radiations relevant in the space environment.
This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.
Moreover Pax6 has been shown to have oncogenic potential and regulate cell growth in cultured human cells and mouse model system (Li and Eccles, 2012; Mascarenhas et al., 2009; Robson et al., 2006; Walcher et al., 2013).
The mechanism must be described for the mouse model system.
The human neuroblastoma xenograft mouse model system is well established [25], [26].
In the mouse model system, XCI occurs in two waves during embryogenesis.
Besides a specific detection tool, a robust mouse model system was required in order to develop a sensitive detection protocol.
