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We also show that the QKCMP can bind to excised tissues from burn injuries in cutaneous mouse model, suggesting its potential for promoting neovascularization of burn wounds.
Furthermore, even in the less well epigenetically defined case of fibromyalgia, mS-11 ameliorated symptoms in a mouse model, suggesting that fibromyalgia is related to the dysfunction of NRS F/REST
Importantly, in vivo studies showed that this synergism was able to generate significantly increased new bone in an ectopic mouse model, suggesting that PCL/HA-3D scaffolds act as a favorable synthetic extracellular matrix for bone regeneration.
Key transcriptional programs activated in psoriasis, including IL1-related signalling and cholesterol biosynthesis, are replicated in the mouse model, suggesting that PPARβ/δ regulates these transcriptional changes in psoriasis.
Further, genetic absence of 5-LO results in a significant reduction of brain Aβ levels and deposition in a transgenic AD mouse model, suggesting that this enzymatic pathway plays a functional role in modulating the amyloidotic phenotype of this model [11].
Neuronal precursors of the DMNV were detectable at E13.5 in the mouse model, suggesting PHOX2B∆8 prevents DMNV formation despite progenitor specification.
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Previous studies of NDV-vectored vaccines in a mouse model suggested their potency after delivery by injection or by the intranasal route.
The minor defects observed in our mouse model suggest a mild effect from ATRX deficiency that may manifest only occasionally.
Results from the mouse model suggested that the transcriptional activity of buffy coat-isolated cells may be used to monitor the onset of and recovery from acute infection.
Conversely, studies from a different independently generated p63 null mouse model suggest that p63 may be required in the commitment step to the stratified epithelial lineages [19].
Recent data obtained using a muscle-specific plectin-null mouse model suggests that plectin is the primary desmin organizer in muscle [3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com