Sentence examples for mouse model results from inspiring English sources

Induction of Nbn null mutation in vivo in this conditional mouse model results in chromosome damage, radiomimetic-sensitivity, cell cycle checkpoint defects and impaired immunoglobulin class switching.

In the present report we show that deletion of Dicer using a newly developed tamoxifen-inducible SMC specific mouse model results in widespread loss of miRNA expression and a dramatic reduction in blood pressure.

Expression of mutant PS1 in a knock-in mouse model results in accentuated inflammatory behavior in microglia [13] and conditioned media from PS1 mutant expressing microglia negatively impact hippocampal neurogenesis [63].

In this regard, Rohn and colleagues have shown that overexpression of the anti apoptotic protein Bcl-2 in the context of a triple transgenic AD mouse model results in lack of pathology, highlighting the contribution of caspases in disease progression [56].

In vivo mouse model results revealed that CCN1 increased the metastatic potential of prostate cancer cells.

Another interesting and recent finding is that the lack of RUNX3 in a mouse model results in eosinophilic airway inflammation.

A Ct Serovar D infection is cleared fast in the mouse model resulting in a narrow window for analysing the protective efficacy of a vaccine.

Furthermore, we have demonstrated that overexpression of Cdk2ap1 in a transgenic mouse model resulted in gonadal atrophy, seminiferous tubule degeneration, and folliculogenesis abnormalities in vivo [12].

More recently, VPA administration in an SMA mouse model resulted in apparent improved motor function, larger evoked motor potentials, less degeneration of spinal motor neurons and improved neuromuscular junction innervation in treated animals compared to age-matched controls [28], [29].

We have previously shown that the MDR TB regimen combining amikacin, moxifloxacin, ethionamide and pyrazinamide has the highest bactericidal activity in the mouse model, resulting in culture conversion after 9 months of treatment [15].

Inactivation of both alleles of DOHH in this novel mouse model resulted in embryonic lethality.