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Furthermore, we have demonstrated that overexpression of Cdk2ap1 in a transgenic mouse model resulted in gonadal atrophy, seminiferous tubule degeneration, and folliculogenesis abnormalities in vivo [12].
More recently, VPA administration in an SMA mouse model resulted in apparent improved motor function, larger evoked motor potentials, less degeneration of spinal motor neurons and improved neuromuscular junction innervation in treated animals compared to age-matched controls [28], [29].
Inactivation of both alleles of DOHH in this novel mouse model resulted in embryonic lethality.
Co-administration of R116010 with 13cisRA in this mouse model resulted in significant increases in plasma ATRA and 13cisRA concentrations.
M-CSF receptor overexpression in an AD mouse model resulted in an increased antibody-opsonized Aβ phagocytosis by microglial cells [ 75].
They also carried out in vitro experiments, which showed that prostate-specific upregulation of SKA1 in a transgenic mouse model resulted in spontaneous tumorigenesis [ 19].
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A Ct Serovar D infection is cleared fast in the mouse model resulting in a narrow window for analysing the protective efficacy of a vaccine.
We have previously shown that the MDR TB regimen combining amikacin, moxifloxacin, ethionamide and pyrazinamide has the highest bactericidal activity in the mouse model, resulting in culture conversion after 9 months of treatment [15].
The ob/ob is an obese, insulin resistant mouse model resulting from the spontaneous mutation of the ob gene encoding the leptin protein [ 40].
Garzia et al (2009) also more directly demonstrated that miR-199b-5p miR-199b-5p miR-199b-5pthe cancer stem-cell poverexpression xenogreducesuse model, resultheg in impaired medulloblastoma tumour development.
Selective ablation of PR-B in a mouse model, resulting in the exclusive production of PR-A, revealed that PR-B is necessary for breast formation [ 13].
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