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The individual categories within PhenoBase are populated with terms extracted from autism-specific mouse model reports and review articles.
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A DNA tetrahedron was used to deliver RNA Interference (RNAi) in a mouse model, reported a team of researchers in MIT.
Previous animal models for IBMPFD include the knock-out mouse model reported by Muller et al (2007) [30].
This complemented earlier studies in this mouse model reporting robust PER2::LUC expression in peripheral tissues including the pituitary gland [46].
A recent study in PyMT-MMTV breast cancer mouse model reported that PTHrP expression level was correlated with breast cancer metastasis and tumor cell survival [ 21].
The endotoxic shock mouse model reported by Rosello et al.[ 30] showed that the levels of PGE2 were significantly lower in the ibuprofen-treated group than in controls.
In contrast, in the new Coq9 Q95X mouse model reported here, the lack of COQ9 protein results in decreased levels of only COQ7 and COQ5 proteins, which leads to moderate CoQ deficiency and a mild mitochondrial myopathy, especially evident in females.
3 4 5 In 2000 Ando et al published the first study examining statins and sepsis in a mouse model, reporting that pretreatment with cerivastatin improved survival and decreased production of cytokines and nitric oxide.
Early studies of this effect in the Nf1 +/− mouse model reported increased astrocyte proliferation but not OPG formation (Bajenaru et al., 2001; Bennett et al., 2003; Gutmann et al., 1999; Rizvi et al., 1999).
Another study on lupus mouse model reported that STAT4-deficient NZM mice developed accelerated nephritis and displayed increased mortality in the absence of high levels of anti-double-stranded DNA antibodies (anti-dsDNA Abs) and in the presence of relatively reduced levels of IFN-γ.
Previous investigations have shown that trastuzumab is effective only in cancer cells that are primarily dependent on oncogenic HER/ErbB2 receptor mitogenic signaling [ 33] whereas other studies using the NIH3T3-HER2 model model reported that cancer cells can be ErbB2-dependent, yet still display resistance to trastuzumab treatment [ 33].
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