Sentence examples for mouse model replicates from inspiring English sources

The CVN-AD mouse model replicates multiple AD hallmark pathologies, and we identified multivariate biomarkers characterizing a brain circuit disruption predictive of cognitive decline.

Since one pathological feature in MSA patients covers selective neuronal loss in the SNc, and the (PLP -αSYN mouse model rePLP -αSYNthis feature, we evaluated whether mousereatmodelhad an effect on numbereplicateseurons.

Thus, neither of the two mouse models replicates the severe muscle phenotype and pathology seen in humans.

The mouse models replicates the disease course in humans, clinical features and complications of SS and gives researchers insights into the disease pathogenesis.

The available knockout mouse models replicate several clinical and biochemical features of infantile GM1-gangliosidosis with low levels of βgal activity (<4% of normal) and massive accumulation of GM1-ganglioside and GA1 glycosphingolipid throughout the CNS [6], [7].

We have previously shown that primary-tumor derived orthotopic xenograft mouse models replicated the histology, invasive growth, and genetic abnormalities of pediatric brain tumors [ 45, 50].

Development of mouse models replicating mitochondrial disease phenotypes has provided a unique opportunity both for therapeutic trials and for detailed studies of molecular pathophysiology of primary mitochondrial dysfunction.

TGF-β expression and activity are increased in human RDEB and in mouse models replicating the disorder (Fritsch et al, 2008; Ng et al, 2012; Kuttner et al, 2013; Nystrom et al, 2013).

The mouse models replicate several features of the human disorder and their analysis implies or excludes the contribution of individual genes or sets of genes for phenotypes such as increased sociability, growth retardation or reduced brain growth.

Both mouse-models replicate the NCL phenotype and neuropathology; the Cln1-/ model presents with early onset, severe neurodegenerative disease, whereas the Cln5-/ model produces a milder disease with a later onset.

A mouse model that replicates the clinical features of the most common form of heart failure opens a window on the mechanisms underlying this disease, and could help scientists to explore future therapies.