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Interestingly, similar observations were made with a Gli2-null mouse model, reinforcing the theory of Hh paracrine signalling in breast tumours [ 27].
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Furthermore, SCG10 has been previously identified as a downregulated gene in a RET mouse model for HSCR [10] reinforcing the idea that SCG10 might also play a role in HSCR development.
This similarity of results achieved in mouse and fish models reinforces the validity of exploiting the latter to study NAFLD.
Therefore, each mouse model is potentially important not only for reinforcing the existence of common or even universal mechanisms of disease but also for revealing unique aspects not yet reflected in the other models.
This hypothesis is reinforced by a transgenic mouse model showing spontaneously reduced eating alongside robust circadian rhythms and increased life span.
The important role of FKBP51 in melanoma progression was reinforced by studies in this mouse model of metastatic melanoma using FKBP51siRNA as a therapeutic approach.
They reinforce the validity of the adopted mouse model to study prevention strategies against human breast cancer and highlight the need for further investigations into the molecular changes following late versus early pregnancy.
This suggests that fth gene expression is sensitive to proteinuria, a hypothesis which is reinforced by proteomic work on the OVE26 transgenic mouse, another mouse model for type 1 diabetes [ 23].
"Blocking tumor necrosis factor in a mouse model improves asthma," Dr. Remick said.
"We had the virus, the mouse model, and two vaccines to test".
But here's the problem -- each mouse "model" is different and no single mouse "model" shows all the pathologic features of AD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com