Additionally, pharmacokinetics, biodistribution, and clearance route are studied after intravenous injection in a mouse model, reflecting their overall safety.
In addition, pharmacokinetics, biodistribution, as well as clearance of nanoparticles were studied after intravenous injection in a mouse model, reflecting their overall safety.
We first evaluated the antifibrotic properties of the monoclonal anti-IL-6R antibody, MR16-1, in the bleomycin-induced dermal fibrosis mouse model, reflecting early and inflammatory stages of SSc.
In order to develop and standardize a mouse model reflecting the human situation of metabolic syndrome with diet-induced obesity, adipose tissue inflammation promoting insulin resistance and atherosclerosis we investigated the effect of a common high-fat diet and a sucrose-enriched high-fat diet in LDLR-/ mice.
None of these two mouse models reflects human AD pathology because none showed significant neurofibrillary tangle pathology and both overexpressed a transgenic construct made to produce large amounts of Aβ [ 16, 20].
Eltokhi, A., Rappold, G. & Sprengel, R. Distinct phenotypes of Shank2 mouse models reflect neuropsychiatric spectrum disorders of human patients with SHANK2 variants.
The evaluation should focus on protection from the acute stage of infection in both mouse models, reflecting the need to protect humans from rapidly fatal disease.
In addition, it is important that mouse models reflect the events that are common in human ILC pathology such as lymphatic dissemination and subsequent distant metastasis, especially to bone.
Finally, although the precise cellular origin of splenic PrPd in TgOvPrP4 ovine transgenic mice still needs to be determined, our data suggest that this ovine transgenic mouse model properly reflects the behavior of the different TSE agents in sheep with regard to their capacity to propagate in the spleen.
