Sentence examples for mouse model recapitulating from inspiring English sources

More strikingly, in a mouse model recapitulating the retinal degeneration affecting SCA7 patients, the retinopathy correlated with a global repression of genes specifically involved in photoreceptor function and morphogenesis, suggesting an alteration of the neuronal differentiation program [15], [16].

We evidenced the occurrence of fibrosis in vivo using a mouse model recapitulating the aggressive course and liquid phase of peritoneal PEL 25.

In this work, we successfully developed and characterized a mouse model recapitulating a major step of the disease: the formation of Mikulicz cells.

Using a 'humanized' knock-in mouse model recapitulating a human dominant-negative point mutation in the nuclear receptor PPARγ, no significant alterations were detected in basal cardiac parameters (e.g. Hw/Bw ratio) or fibrosis level.

In summary, here we provide evidence using a humanized mouse model recapitulating a well-characterized human mutation that defective PPARγ function synergises with high blood pressure to induce cardiac fibrosis in vivo.

This tractable mouse model recapitulates recent findings in human pre-B ALL and allows comparison of wild-type and mutant RAG2.

This widely used mouse model recapitulates many of the key features of human HD.

Our Snord116del mouse model recapitulates the abnormal feeding behavior in human PWS.

Thus, the αB-crystallin R120G knock-in mouse model recapitulates the key symptoms of human hereditary myopathy and cataract disease pathology.

Undue activation of Raf signalling is a key event in lung adenocarcinoma and this mouse model recapitulates the genetic events associated with the different stages of tumor development, i.e. from low to high grade dysplasia to highly and less differentiated adenocarcinomas.

Given this, our mouse model recapitulates human T-lymphomagenesis more closely than the Roquin model.