Exact(4)
In conclusion, this study demonstrates that bioluminescent N. meningitidis strains together with the CD46 transgenic mouse model provide a potent tool for in vivo investigations of meningococcal disease.
Importantly, recent studies on HSF1 knockout mouse model provide compelling genetic evidence for the existence of a critical oncogenic cooperation between mutp53 and HSF1.
Data obtained from this mouse model provide evidence for an association between depression and altered circadian rhythms at the genetic level and point towards a role for Cry2.
iTRAQ is a powerful tool for comparative proteomics study of PBC mouse model and differentially expressed proteins in mitochondria proteome of PBC mouse model provide insights for the pathogenesis mechanism at early stage of PBC.
Similar(4)
Altogether, the proposed ER+/ERαKD tumor-bearing mouse model provides a promising preclinical platform to investigate novel ER-specific therapies using PET imaging.
Small-molecule drugs that help to fold and process proteins correct type 2 diabetes in a mouse model, providing a new lead for the treatment of human diabetes.
In summary, this mouse model provides important insights into CLC development and suggests inhibition of phosphatidylinositol 3-kinase (PI3K) signaling as a potential therapeutic strategy for targeting CLC.
Although 10-fold greater quantities of antibody are required to observe significant effects in mouse, compared to our previous studies in rats, the present mouse model provides a convenient paradigm for investigating catalytic and non-catalytic antibodies.
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