In fact, only at the end of week 3 (late MM stage in mouse model), the presence of MDSC in spleens declined, without any difference in the kinetics for G-MDSC or mo-MDSC.
Taken together, these data suggest that in our mouse model the presence of the dominant-negative PPARγ mutation may have impaired the repressor function of PPARγ in preventing cardiac fibrosis during AngII challenge, thereby allowing enhanced transcription of these particular profibrotic genes.
In amyloid precursor protein (APP) mouse models, the presence of human apoE4 has been associated with accelerated deposition of Aβ in the brain.
As IFNs play an eminent role in human pSS pathogenesis, we studied the NOD mouse model for the presence of systemic IFN activation and found no indication for the presence of a systemic IFN signature (McGuiness B, Beumer W and colleagues, unpublished work).
Collectively, we demonstrated that miR-17~92 miR-17~92d tumor progresuppressednhibitumortumor angiogenesis in a genetically engineered mouse model, indicating the progression cellular context-dependent pro- and anti-cancer effects of miR-17~92.
Here, we present a novel mouse model where the presence of a single autoreactive B cell clone drives the TLR7-dependent activation, expansion, and differentiation of other autoreactive B cells in spontaneous GCs.
Subsequent immunohistochemical studies using the APP/PS1KI mouse model revealed the presence of plaque-associated and intraneuronal pyroglutamate Aβ3 x [ 8] or in spinal cord motor neurons [ 105].
More recently, the use of pimonidazole (hydroxyprobe®), a marker of oxygen partial pressures <10 mmHg, in the mouse model identified the presence of hypoxia during simulated menstruation (Fan et al., 2008).
To begin to understand how WDLPS and DDLPS differ molecularly in this mouse model in the presence of p53 and PTEN deletions we ran gene expression microarray analysis to compare the two different LPS tumor types.
Despite the relative lack of oligomeric or fibrillar tau species, a prominent feature of this mouse model is the presence of grossly dilated axons that are prevalent in the spinal cord, hindbrain and cortex and also detectable in the striatum.
