Sentence examples for mouse model phenotypes from inspiring English sources

To achieve this goal, we first integrate mouse model phenotypes and drug effects, and then systematically compare the phenotypic similarity between mouse models and drug effect profiles.

Zhang et al. [21] used advanced bioinformatic methods to explore the extent of gene sharing between a broad range of human and mouse model phenotypes.

While key features of human psoriasis were recapitulated by mouse model phenotypes, points of non-correspondence relative to each other and to human psoriasis were also identified.

We therefore identified sets of genes associated with such in vitro KC responses to cytokine treatment and evaluated how these gene sets were altered in both psoriatic skin from humans and lesional skin from mouse model phenotypes (Figure 10).

Results: We investigate the use of mouse model phenotypes for drug target identification.

We obtained only mouse model phenotypes associated with models resulting from loss-of-function mutations in single genes.

Genetically engineered mouse model phenotyping has an increasing pivotal role in bridging preclinical and clinical development.

Indeed, although the ΔNp63 knockout mouse models have phenotypes that are similar to the full p63−/− mouse model, their phenotypes are not completely identical to the phenotype observed with total p63 ablation.

The adenomatous polyposis coli multiple intestinal neoplasia (ApcMin/+) mouse model presents phenotypes reminiscent of Familial Adenomatous Polyposis (FAP) in humans [18], [19].

We tested the mouse model for phenotype prediction capabilities.

We begin with a brief overview of the principal clinical features of RTT, which is a necessary foundation for evaluating the degree to which existing mouse models reproduce phenotypes of the human disease, and for identifying sensitive and relevant outcome measures for preclinical and clinical trials.