Sentence examples for mouse model overexpressing from inspiring English sources

We have generated a transgenic mouse model overexpressing DSCR1/RCAN1 in the brain and analyzed the effect of RCAN1 overexpression on cognitive function.

Here, we use a humanized mouse model overexpressing Tcf7l2, resulting in glucose intolerance, to infer the contribution of Tcf7l2 overexpression in beta cells and in other tissues to the metabolic phenotypes displayed by these mice.

A tauopathy mouse model overexpressing the 0N4R human tau isoform carrying the P301L mutation linked to familial frontotemporal dementia.

A tauopathy mouse model overexpressing the 1N4R human tau isoform carrying the P301S mutation found in patients with frontotemporal dementia.

Mougenot, A. L. et al. Transmission of prion strains in a transgenic mouse model overexpressing human A53T mutated alpha-synuclein.

We therefore generated a dystrophic mouse model overexpressing Nfix downstream a skeletal muscle promoter, taking advantage of Tg Mlc1f-Nfix2 mice17.

In the first instance, our previous transgenic mouse model overexpressed a dominant-negative Rorα1 transcript, specifically in skeletal muscle [ 17].

This discrepancy between mouse and rat models targeting the ERBB2 pathway may be due to the fact that the mouse model overexpressed the mutated form of ERBB2 [ 32], whereas the rat model overexpressed nonmutated ERBB2 [ 111] and rat tumors were strongly AR-positive while mouse tumors had low AR immunopositivity.

Moreover, neuronal hyperexcitation occurs in transgenic mouse models overexpressing amyloid precursor protein and its pathogenic product, amyloid β protein (Aβ).

Second, some mouse models overexpressing non-mutated forms of PrPc [40] [42] displayed neurodegenerative symptoms.

However, the involvement of Dyrk1A in cognition has only been investigated in transgenic mouse models, overexpressing the gene.