Sentence examples for mouse model observed from inspiring English sources

The most prominent cardiac dysfunctions in the APP/PS1 AD mouse model observed in our study were reduced cardiomyocyte contraction and diminished maximal velocity of contraction/relaxation (±dL/dt) at both low and high stimulus frequencies associated with unchanged duration of contraction and relaxation.

Furthermore, the study of a Dnmt1 +/− mouse model observed a lower DNA methylation level, which led to impaired learning and memory functions in an age-dependent manner [ 80].

A recent study using a CD-1 mouse model observed higher body weight and increased insulin and leptin levels in post-pubertal female offspring after low-dose in utero exposures to PFOA (Hines et al. 2009).

Harraz et al. have used oral apocynin to control progression of neurodegeneration in a SOD1 mutant mouse model and observed promising effects [ 30]; it was observed that administration of apocynin in the drinking water significantly prolonged survival and delayed the onset of motoric defects.

To address the role of hypoxia in HIF-1α regulation, we prevented menstrual hypoxia in our mouse model and observed a significant reduction in HIF-1α protein.

Intraperitoneal administration of H72 significantly inhibited the growth of MGC803 cells in vivo in a xenograft mouse model without observed toxicity.

Using a humanized mouse model, we observed that T cells expanded in the absence of human serum provided durable control of tumors, whereas T cells expanded in medium supplemented with human serum only mediated transient control of tumor growth.

In the Snord116 deletion mouse model, we observed normal locomotor activity and excellent wire-hanging ability.

In a glioblastoma xenograft mouse model, we observed that ectopic expression of hTERTC27 in tumor cells induced tumor regression and significantly prolonged survival of tumor-bearing mice.

In a 6 weeks old CD1 septicemic mouse model, we observed that PilB was dispensable for bacterial virulence in both genetic backgrounds.

Human orthologs of genes identified in the stromal reaction to tumor progression in this mouse model were observed to be expressed in several human cancers, and to cluster prostate and breast cancer patients into groups with statistically different clinical outcomes.