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Although in the mouse model, no additive effect of 4%% oxygen could be demonstrated when 5%% of N2O or more was used [25], we preferred to use also 4%% of O2 for this exploratory trial since 4%% of oxygen when used alone had a small effect on postoperative pain in women [30].
For the mouse model, no protective titer has been defined.
In the synapsin-Cre-based Tsc1 mouse model, no evidence of astrogliosis was observed (37).
Nonetheless, there was work demonstrating that, in a SCA 7 knock-in mouse model, no significant impairment of the UPS was found [ 183].
Mice lacking Abca1 have impaired glucose tolerance [ 11] although in the LDLr knockout mouse model no associations were observed between the quantitative trait loci of atherosclerosis and levels of total cholesterol, HDL-C, insulin or body weight [ 12].
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In these mouse models, no causal connection has been made between the genetic background of the mice and NOTCH activation.
For HD mouse models, no differences in striatal Bad protein levels were found between R6/1 and littermate controls.
Despite the reported success of the immunomodulatory effects of statins in mouse models, no increased effects were appreciated in mice treated with the combination treatment compared to those receiving L-4F alone.
In the mouse infection model, no bacteria were detected by means of plating the lung homogenates of LVX-treated mice at day 4 after infection, while more than 105 CFU of bacteria per tissue sample were detected in nontreated mice.
Furthermore, an independently generated non-cleavable MLL mouse model showed no overt proliferation defects in MEFs.
The Prm1-bPAC mouse model shows no change in fertility parameters.
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CEO of Professional Science Editing for Scientists @ prosciediting.com