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Here, we extend that approach to an autochthonous mouse model, namely the Apc min /+ mouse, which develops multiple intestinal adenomas as a result of Wnt pathway activation.
ASCs also have anti-inflammatory effects via inducing immune tolerance in a RA mouse model, namely, type II collagen-induced arthritis (CIA) mice [ 16].
Consequently, we investigated the growth inhibitory effect of YM529 in a mouse model, namely, a left-ventricular implanted bone metastatic model.
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Intensity of autophagy was evaluated in central and peripheral lymphoid organs from two distinct lupus-prone mouse models, namely MRL lpr/lpr and (NZB/NZW F1 (NZB/W) mice.
The newly described genetically engineered mouse models, namely the KP and KPC mouse, better recapitulate the impact that inflammatory and stromal cells have in the pathogenesis of PDAC [ 14].
For instance, it has been shown that the ablation of CX3CR1 in AD mouse models, namely APP/PS1 and R1.40, attenuates Aβ deposition by modulating the phagocytic activity of microglial cells [ 57].
Since angiogenesis plays a key role in RA, we next evaluated the therapeutic potential of ASV in an extensively validated mouse model of arthritis – namely, acute CIA.
Therefore, in the current study, we examined the effect of oleocanthal on Aβ load in the brain parenchyma of a mouse model of AD, namely, TgSwDI mice, and on Aβ deposit on brain microvessels.
The studies described in this report demonstrate that the potent human EGFR HER1/HER3 ECD heterodimer RB200 has a significant abrogating effect in a mouse model of RA, namely, CIA.
They used a different mouse model of Marfan syndrome, namely the Fbn1MgR/MgR model.
In 2006, the effect of resveratrol on lifespan of mammals, namely a mouse model of obesity, was reported by two groups: Sinclair's and that of Johan Auwerx (Baur et al 2006; Lagouge et al 2006).
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