Although most murine models of inflammatory bowel disease develop inflammation in the colon, Crohn's disease most commonly occurs in the terminal ileum, where a very limited number of mouse models manifest disease.
About 12 years ago, Gudas and Tang, then a postdoctorate, developed a mouse model that manifests oral cavity and esophageal squamous cell carcinoma, a cancer that forms from epithelial stem cells.
A rat model with chronic rotenone exposure seems to reproduce pathophysiological conditions of PD more closely than acute mouse models as manifested by neuronal cell death in the substantia nigra and Lewy body-like cytosolic aggregations.
We utilised two mouse models, each manifesting distinct AD-related pathologies: the K3 tau transgenic model, which develops NFTs [ 21, 22]; and the APP/PS1 transgenic model, which develops amyloid plaques [ 23].
A list of naturally occurring and chemically induced mouse mutants as well as genetically engineered mouse models that manifest retinal disease is provided in Table 2 and supplementary material Table S1.
In the mouse model, again which does not manifest any dengue disease, protective efficacy is measured in terms of survival after lethal DEN virus challenge.
In the last few years our laboratory has been studying a mouse model of type 2 diabetes, which manifests hyperinsulinemia and dyslipidemia, namely the MKR+/+ mouse model.
To test his theory, he created a mouse model for lymphedema — the disease would manifest in the animals' tails — and treated it with ketoprofen, a nonsteroidal anti-inflammatory drug, or NSAID.
Here we describe a metastatic CRC mouse model and show that liver metastases can manifest without a lymph node metastatic intermediary.
Moreover, cardiac myocytes isolated from a mouse model with 80% reduction in AIF levels manifested increased cell death induced by oxidative stress, and the hearts of these mice displayed enhanced ischemic damage after in vivo I/R.
