Sentence examples for mouse model leading from inspiring English sources

Another confirmation for the link between the lung vasculature and alveologenesis has been demonstrated convincingly by induced endothelium-specific deletion of Vegfr2 and Fgfr1 in a pneumonectomy mouse model leading to impaired compensatory lung growth [48].

It is important to note that IAPs have been shown to have their methylation patterns affected by nutrition in the Agouti mouse model, leading to a concomitant change in coat color [80], [81].

Furthermore, ablation of Smurf2 leads to dysregulation of the epigenetic landscape through histone modifications and thus loss of chromosomal stability in a mouse model leading to a wide range of malignancies including lymphomas.

In addition, multivesicular bodies, late endosomes and specifically ESCRTs have also been shown to play a role in the life cycle of microRNAs [ 15, 23], and it was recently reported that microRNA-124 is decreased in another CHMP2BIntron5 mouse model, leading to an alteration in AMPA receptor composition, which may also contribute to aspects of the disease phenotype [ 13].

Matrix metalloproteinase 9 (MMP9) is a protease known to break down the ECM, and MSC have been shown to increase the expression of MMP9, along the fibrous septa in mouse models, leading to regression of fibrosis (37).

Rapoport et al. [ 53] prepared paclitaxel-loaded perfluorocarbon nanoemulsions stabilized by biodegradable amphiphilic block copolymers, which were systemically injected into mouse models, leading to efficient tumor regression in pancreatic, ovarian, and breast cancer models under the action of ultrasound (1 MHz).

We recently demonstrated that the conversion of mutant SOD1 from a soluble form to insoluble aggregates by crosslinking through intermolecular disulfide bonds via oxidation of cysteine residues in SOD1 is associated with ALS-like phenotype in transgenic mouse models, leading to a hypothesis that oxidation-mediated SOD1 aggregates underlie such a toxic property of mutant SOD1 (5, 6).

Also, the use of chemotherapy to induce senescence has been shown to be successful in mice models, leading to an anti-tumor effect with a corresponding increase in p16Ink4A[ 54].

However, the expression of the α-Cre transgene is not topographically homogeneous in this mouse model [16], leading to different degrees of gene inactivation within the same organ.

Furthermore, the results in vivo suggested that shRNA NET-1 could significantly downregulate the expression of NET-1 in nude mice xenografts models, leading to stunt the tumor growth and downregulate malignant phenotype of tumor.

Administration of PDGF-BB increased in vivo growth of lymphatic vessels in a mouse corneal model and in a murine fibrosarcoma xenograft model, leading to increased lymphatic metastasis.