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Importantly, the A53T α-Syn+/+ mouse model involves an age-dependent neurodegeneration.
A well-described mouse model involves a CM-susceptible strain (C57BL/6) infected with the rodent malaria parasite, Plasmodium berghei ANKA (PbA) [8].
(7) Our use of the intravenously-challenged mouse model to measure bacterial gene expression in vivo may not exactly reflect events that occur during natural infection (since the mouse model involves neither spore germination nor formation); however, using this model, we were still able to detect induction of a number of IVIAT identified genes or paralogs in vivo.
Akin to human PE, this spontaneous mouse model involves an imbalance in angiogenic factors, including VEGF and sFlt-1.
Similar to the HIS mouse model, the HIV encephalitis (HIVE) mouse model involves grafting human immune cells into severe combined immunodeficient (SCID) mice.
One mouse model involves a four-generation breeding scheme that produces C57BL/6 XXY and XY mice in the same litters [ 51- 53].
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In addition, a mouse model involving limited deletion of PTEN in the cerebral cortex and hippocampus resulted in mice with macrocephaly, abnormal social interactions, and increased sensitivity to sensory stimuli, characteristics that are often associated with ASD [70].
Experiments in the mouse model involved 4 6 animals per group, in up to three independent experiments.
This study describes the first successful PHA2E mouse model involving CUL3 and highlights the molecular differences and defects of the mutant CUL3 protein.
However, Amaro et al. [ 77] previously reported that ATCC 33149 was of modest virulence in a different mouse model involving intraperitoneal infection.
Our third best match for this syndrome from all 27 251 MGD mouse models is a mouse model involving a targeted insertion to knock-out all function of the Rspo2 gene: B6.Cg-Rspo2 / Rspo2 (http://www.informatics.jax.org/accession/MGI 3839444).org/accession/MGI 3839444
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