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This further emphasises the potential of using our mouse model instead of traditional human cohorts for downstream genome-wide association scans.
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Limitations included: description of a single metastatic site or tumor suppressor gene, non-matched pairs of primaries and metastases, methylation only in the primary tumor (compared to the metastasizing tendency), or the use of mouse models instead of patient material [ 11, 12, 22– 26].
A similar study was performed by [97], based on a heterogeneous mouse model rather than on an homogeneous one and using SPECT instead of PET for validation.
Although previous research has suggested that selfish QS-regulated traits could be relevant in infections and could drive the spread of resistance to QSIs, recent experiments with mouse infection models instead match these results in protease-selective media very well.
In consideration of this comment, we have decided not to classify this mouse model as CCD but instead have used a broader term of a "myopathy with core-like structures".
This animal model was chosen instead of the mouse model, since a H. pylori type I-strain is instable in the mouse and rapidly switches off the cag-T4SS.
To investigate the possible causal link between NANOS3 dosage and POI, we generated a mouse model with attenuated Nanos3 transcription levels instead of making an R133W knock-in mouse, as mNANOS3 stability was less sensitive to degradation affected by the R133W mutation.
Major issues: 1) The KO mouse model was generated by a gene-trap strategy instead of a targeted approach.
In our study, we instead used an infiltrative glioma mouse model, which more closely reflects the nature of infiltrative glioma that has an indistinct margin [ 7, 8].
Instead, lineages II and III are considered low pathogenic in the mouse model [ 3]. T. gondii infections are widely prevalent in humans and animals worldwide [ 6].
Mouse model of MDD.
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