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Passive administration of these Abs in a xenogeneic melanoma SCID mouse model inhibited tumor growth up to 40% and 62% in a therapeutic and prophylactic setting, respectively [13].
Injection of both allogeneic and syngeneic cMSCs in an AD mouse model inhibited cell infiltration in skin lesions and decreased the serum level of IgE.
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Silencing of Plac8 in cell lines suppresses tumor formation by blocking autophagy, a process essential for maintaining metabolic homeostasis in PDA, and genetic inactivation in an engineered mouse model inhibits PDA progression.
2-DG was then evaluated in two mouse models, inhibiting angiogenesis in both the matrigel plug assay and the LHBETATAG transgenic retinoblastoma model.
In a hepatic fibrosis mouse model, LA inhibited the expression of Col I, αSMA and PAI-1 [ 35].
Using a nude mouse model, CDK11p58 inhibited the growth and density of microvessels of the transplanted tumor.
In ventricular myocytes isolated from a catecholaminergic polymorphic ventricular tachycardia mouse model, flecainide inhibited cardiac ryandodine receptor channels by open-state blockade, significantly reducing the spark Ca2+ mass without causing any compensatory increases in the sarcoplasmic reticulum Ca2+ content.
Further ectopic expression of miR-24 in a mouse MI model inhibited cardiomyoblast apoptosis, attenuated infarct size, and reduced cardiac dysfunction [ 22].
We report here that SIRT1 suppresses intestinal tumorigenesis in the APCmin/+ mouse model and inhibits colon cancer growth.
For example, IL-10 has been shown in a collagen-induced arthritis (CIA) mouse model to inhibit paw swelling and an increase in arthritic score [ 30- 33].
Both PGRN and Atsttrin prevented inflammation in various arthritis mouse models and inhibited TNFα-induced intracellular signaling pathways.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com