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Similarly, in vivo evaluations in KP mouse model indicated successful CD44/EGFR-targeted delivery.
Preclinical assessment of p52−/p36− GAP in a humanized mouse model indicated an early and severe liver stage growth defect.
In conclusion, the mouse model indicated retarded disease progression upon cessation or switching to pMRTP which alone had no adverse effects.
The new findings from mouse model indicated the requirement of CREB3L1 for bone formation [ 18].
Our observations on the hypogonadal LHR−/− mouse model indicated that the doses of exogenous T that effectively suppressed gonadotropins and maintained sexual function also activated spermatogenesis.
Recent evidence from a breast cancer mouse model indicated that the Jagged1/Notch pathway promotes osteolytic bone disease of breast cancer through engagement of Notch signalling in osteoblasts and osteoclasts.
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These studies with a mouse model indicate that PAF-AH is not a major secondary target of OP pesticide poisoning.
The efficacy of nintedanib at improving lung function has also been shown in a recent IPF mouse model, indicating that it not only reduces fibrosis but also significantly enhances the pulmonary microvasculature [15].
Inhibiting ATM also prolonged survival of the allograft mouse model, indicating that targeting the DNA damage response pathways alone or in combination with other chemotherapeutic agents may be beneficial in patients with AML.
Collectively, we demonstrated that miR-17~92 miR-17~92d tumor progresuppressednhibitumortumor angiogenesis in a genetically engineered mouse model, indicating the progression cellular context-dependent pro- and anti-cancer effects of miR-17~92.
Open wound healing tests with a mouse model indicate that the catechol-chitosan film suppresses the bacterial population at the wound site, induces less inflammation and promotes wound healing.
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