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Alternatively a mouse model incorporating both would provide some answers regarding the relative contributions of the two mutations to the disease pathogenesis and the normal intracellular roles and interactions of both TDP-43 and FUS.
Most studies use variations of the original nude mouse model, incorporating deepithelialized, diced human abnormal scar tissue in the subcutaneous pockets on the back or thorax of nude, athymic mice, with minor alterations.
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In mouse models incorporating both Aβ and tau pathologies, Aβ and tau proteins were found to act synergistically to inhibit mitochondrial oxidative phosphorylation, and increase cellular levels of reactive oxygen species [16].
Alternatively, "miRNA sponges" have been developed to inhibit miRNA activity in cancer cells and mouse models by incorporating the complementary binding sites of target miRNA into RNA transcripts expressed from strong promoters [132].
For example, in direct contrast to the predictions of the DDC model it has been shown for human and mouse that the number of retentions and losses of duplicates fits more consistently with a model incorporating positive selection [ 14].
Consider first the 1D model, incorporating only the slow dynamics.
Model M3 is the full model incorporating all explanatory variables.
This model of MS in which mice are infected with HSV-IL-2 differs from most animal models of MS that are based on either the autoimmune model [27] or the viral model [21] in that this model incorporates both viral and immune aspects of the disease process.
So our model incorporates direct interaction.
Our model incorporates the sex-ratio imbalance in newborns.
The spreadsheet model incorporates clinical data, treatment patterns, and costs.
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