Sentence examples for mouse model identified from inspiring English sources

Studies on this mouse model identified previously unknown molecular pathways that are induced by GM1 accumulation and result in neuronal apoptosis and neurodegeneration [10], [11].

Mapping of EGF induced liver cancer in a transgenic mouse model identified n = 96 (p < 0.05) significantly regulated proteins of which n = 54 were tumour-specific.

Later, a mouse model identified a putative endogenous GSC located at the apex of a cellular hierarchy that was involved in tumor maintenance and recurrence after chemotherapy.

Further studies using the MST1 deficient mouse model identified that the role of the up-regulated MST1 kinase was to promote the development of muscle atrophy, rather than functions as an adaptive mechanism to prevent rapid loss of muscle mass.

Importantly, varying the proportion of mutant actin in this mouse model identified that disease severity correlated with the ratio of mutant to wild-type protein, suggesting a dominant negative action for ACTA1D286G [ 41].

The previously reported transposon-mediated mutational screen of a pancreatic ductal preneoplasia mouse model identified a series of genes whose targeted inactivation cooperated with KRASG12D in the development and progression of PDA [ 9].

Previous studies using mouse models identified sphinganine variants of α-galactosylceramide as promising iNKT cell activators that stimulate cytokine responses with a strongly proinflammatory bias.

Interestingly, investigation of SS using inbred mouse models identified Gpa33 as one of a handful of genes deleted in two SS susceptibility loci (Nguyen et al., 2008).

Functional evaluation of three analogous human TEX11 missense mutations in transgenic mouse models identified one mutation (V748A) as a potential infertility allele and found two mutations non-causative.

Several studies both in human and based on mouse models identified some regions of human chromosome 21 (Hsas1) as linked to cognitive deficits.

Summary: The comparison of different nephron-specific Wt1-knockout mouse models identifies the stage of origin of human WT1-mutant Wilms' tumours.