Sentence examples for mouse model generated from inspiring English sources

In order to study the disease pathology of PSACH in a more physiologically relevant model, we report the generation and phenotypic description of the first knock-in mouse model generated by homologous recombination and harboring the common D469del COMP mutation.

To this end, we employed a viable SGK1 knockout mouse model generated in a 129/SvJ background.

Design: Using a mouse model generated on a C57BL/6 background (wild type, WT) in which the GOAT gene has been deleted (KO), we measured plasma AG, UAG and GH concentrations and tissue (stomach, pituitary and hypothalamus) preproghrelin and GOAT mRNA in non-pregnant (NP) and pregnant (P), WT and KO mice.

The strong growth retardation phenotype in our Fto deletion mice is consistent with that in the previously reported knockout mouse model generated by a slightly different strategy [31].

At the animal level, the mouse model generated by Hoki et al. which bears in frame deletion of exon 13 RecQ4 shows normal sensitivity to IR and UV irradiation [28].

In this study we used the Rett Syndrome mouse model generated by the laboratory of Adrian Bird [(strain Mecp2tm1.1Bird), Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, UK] [5], [6].

C3HeB/FeJ mice (also known as the Kramnik mouse model) generate hypoxic, caseous necrotic pulmonary lesions with abundant intracellular and extracellular bacteria following LDA infection with M. tuberculosis, and therefore represent an attractive model in which to study TB drug activity.

These aspects have been only partially elucidated using the Fig4-null mouse models generated so far.

Several transgenic mouse models generated to understand the molecular mechanisms of AD also reproduce loss of dendrites and spines.

Many aspects of the molecular pathophysiology of FRDA remain to be addressed using the different mouse models generated.

Mouse models generated via engraftment of primary human tumors into immune-compromised mouse models have become increasingly popular for preclinical testing of anticancer drugs.