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Importantly, circadian BMAL1 expression was in tumour of a mouse model followed by TYMS expression and combined overexpression correlated to low response and worse survival on 5-Fu treatment[49].
Similarly, correction of the βs mutation in murine iPS cells derived from a humanized SCD mouse model, followed by successful transplantation of differentiated hematopoietic cells into isogenic mice, has been applied to cure SCD phenotypes.
The time course and relationships between astrocytosis and Aβ deposition were examined using multitracer in vivo positron emission tomography (PET) imaging in an AD transgenic mouse model, followed by postmortem autoradiography and immunohistochemistry analysis.
Using an isotope-tracing strategy in a mouse model followed by liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis, we were able to follow mC metabolism in RNA.
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After predicting the network linking Apc and Cdkn1a, we evaluated the relevance of these predictions by manipulating the underlying system: generating in vivo network perturbations in two mouse models, followed by systems-level 'omic measurements from the small intestinal epithelium.
In this study, a systemic comparison of three PSPs (a −650/+30 bp PSA, a −426/+28 bp PB, and a Cla I truncated 1.1 kb MMTV LTR) activity and specificity in the canine and mouse models followed by a PSP-driven E1-mediated oncolytic approach on prostate cancer has been conducted.
A time-course study in the mouse ADG model, followed by renal tissues and urine samples from patients with various types of glomerular disorders for ANXA1.
In the mouse model, we followed the protocol of a previous study [ 27].
By using an endothelial-specific lineage-tracing mouse model, we followed the fate of endothelial progenitors during muscle regeneration after an acute injury.
For our dextran sulfate sodium (DSS; MP Biomedicals, Solon, OH; 36 000–50 000 mw) mouse model, we followed the method of Seril et al. (7).
In order to study the transmission of epigenetic marks from paternal chromatin (predominantly H4K12ac and DNA methylation) to the embryo, we used a mouse in vitro fertilization model followed by indirect immunofluorescence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com