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All mouse model experiments and procedures were performed in accordance with the guidelines set by the Institutional Animal Care and Use Committee at Memorial Sloan Kettering Cancer Center.
In the source mouse model experiments [4], RNA hybridization was done on Affymetrix gene chip platform MGU74AV2.
This association study was validated in our mouse model experiments.
The mouse model experiments revealed that SIRT1 overexpression significantly enhanced metastatic nodules.
However, the other studies mentioned were based on mouse model experiments [ 5, 6], whilst the present study included ICU patients.
Mouse model experiments indicate that the extended storage of embryos/oocytes does not affect the outcome of thawed cycles [ 17].
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We then study data from a two-way, two-source, n≪ p, so far unpublished lung cancer mouse model experiment.
In a mouse model experiment, infection of the brain with Venezuelan equine encephalitis virus resulted in a serotonin presynaptic deficit and postsynaptic hyperreactivity of the serotonin system (12 ).
In addition, a recent mouse model experiment [ 72] has demonstrated that P53 was critical in the liver-stage infection of malaria.
After ruling out major tumor-supporting effects of ketone bodies in vitro, we performed an orthotopic xenograft mouse model experiment to assess whether this ketogenic diet might result in a tumor-selective energy deficit and thus reduce tumor growth in vivo.
To provide maximal experimental utility and enable the translation of preclinical mouse modeling experiments into human disease, GEMMs of human CRC must be driven by homologous allelic series, and exhibit similar clinical presentations to the human disease, including disease histopathology and appearance of metastatic lesions (Heyer et al., 2010; Roper and Hung, 2012).
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