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The global similarity between expression patterns in human psoriasis and mouse phenotypes was statistically significant for each mouse model evaluated.
Nevertheless, at a global level, there is strong and statistically significant similarity between expression patterns in clinical psoriasis and those of each mouse model evaluated by our study.
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This idea lead us to design inactivated vaccines, in a previously established mouse model, evaluating different inactivation procedures and new adjuvants.
It should be noticed that the mouse model evaluates epididymal sperm in different maturation stages until mature spermatozoa [ 6], whereas our study has been conducted on ejaculated spermatozoa.
For example, in a mouse model evaluating the effects of in utero ethanol exposure from days 9 to 11 of gestation, this acute ethanol administration resulted in lower-than-normal methylation throughout the genome (i.e., in global hypomethylation) of fetal DNA (Garro 1991).
Using the mouse model, we evaluated whether PADRE could improve adjuvant-assisted immunizations with a recombinant malarial protein containing the 19 kDa C-terminal region of merozoite surface protein 1 (MSP119) that is a Plasmodium vivax vaccine candidate.
In a mouse model, we evaluated the effectiveness of intradermal injection of plasmid DNA followed by noninvasive in vivo electroporation (EP) as a method to improve transfection in skin.
Recent mouse model work evaluated these different types of antigen-BCR interactions in the Eμ-TCL1 transgenic mouse model of CLL.
Following our results obtained with MR16-1 in the bleomycin mouse model, we evaluated the antifibrotic effects of IL-6 inhibition with an innovative anti-cytokine strategy.
To further confirm the impact of JMJD2B on in vivo tumour growth and DDR, we generated a mouse model and evaluated the effect of targeting JMJD2B with siRNAs.
The feasibility of using food intake and fecal output as simple, clinically relevant endpoints for monitoring ileus in a conscious mouse model was evaluated by assessing the severity and time course of various insults known to cause ileus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com