Sentence examples for mouse model development from inspiring English sources
In this paper we first describe the basic principles behind mouse model development and evaluation and then articulate that current models of depression are intrinsically devalued due to poor construct and/or external validity.
The mouse model development was modified as highlighted by Chang et al. [ 15, 40].
We also discuss new technologies in mouse model development and the perspectives for the future of this field.
The results presented herein demonstrate the antitumoral action of HB-19 in the transgenic RET mouse model against development of spontaneous cutaneous melanoma and visceral metastasis.
In the C57BL/6.NOD- Aec1Aec2 mouse model, the development and onset of autoimmunity in the exocrine glands are considered the results of acinar cell apoptosis that signals an influx of leukocytes expressing pro-inflammatory cytokines.
The question of how these genotypes might result in a particular clinical phenotype is unclear, but the work of Sherlock and colleagues would suggest that in a mouse model the development of enthesitis may be linked to the presence of a particular subset of T cells (IL-23R+, CD3+CD4−CD8−).
This is best evidenced by determining the BRCA1 germline mutations as genetic predispositions in breast cancer, in which the definitive conclusion for its contribution to breast cancer is based on the mouse models showing development of breast cancer with the germline mutated BRCA1[ 42].
Moreover, when gut vascular development was impaired, either genetically in Vegfa120/120 or Tie2-Cre Nrp1fl/− mice or using an in vitro Wnt1-Cre Rosa26Yfp/+ mouse model of ENS development, ENCC still colonised the entire length of the gut, including the terminal hindgut.
After mouse and human model development, additional PBDE congeners will be incorporated into the model and simulated as a mixture.
A dominant-negative Gjb2 R75W transgenic mouse model shows incomplete development of the cochlear supporting cells, resulting in profound deafness from birth [Inoshita A et al. (2008) Neuroscience 156:1569–1567].
Additional studies have shown that periostin supports tendon formation in an ectopic mouse model of the development of tenogenic tissue (Noack et al., 2014).
