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A new mouse model described may help explain why.
Now, a new mouse model, described in the current issue of the Proceedings of the National Academy of Sciences, may help researchers understand agouti's role in regulating body weight--information that may lead to new drugs for treating obesity.
Such studies may be facilitated by the CgB-ko mouse model described here.
Our mouse model is similar to another TLX1-T-ALL mouse model described in the recent De Keersmaecker study [44].
In the PAM mouse model described here we have also found that the disease incidence and severity decreased with parity.
The advantage of using the IFNβ reporter mouse model described here is that IFNβ production can be monitored directly on the cellular level by means of YFP production which allows for a more detailed phenotypical and functional FACS characterization directly ex vivo.
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Previous data from the Tfm (ARKO) mouse model describe significant changes in expression levels and activity of steroidogenic enzymes, which have been attributed to the loss of AR in adult Leydig cells (19, 20, 22).
This review describes the state-of-the-art for generating such models, provides an overview of the types of genetically humanized mouse models described to date and their applications in basic research, drug discovery and development and to understand clinical drug toxicity.
Further work in the SCID mouse models described in this review should yield important new information related to transplantation of human hematopoietic stem cells across HLA barriers, characterization of hematopoietic development in vivo, and identification of pathogenic human T cell clones in organ-specific autoimmune diseases.
The novel mouse models described here will be useful tools for future studies addressing this question in more details.
Similar to the lung cancer mouse models described above, in these EGFR mutated lung cancers behave in an oncogene-addicted fashion following treatment with EGFR tyrosine kinase inhibitors [33], [63].
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