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Results of anti-diabetic assay using C57BL/KsJ-db/db mouse model demonstrated that compound 9 was effective at lowering blood glucose, total cholesterol and HbA1c (P < 0.01).
Preclinical studies in a mouse model demonstrated that the IL-6/sIL-6R based vaccine is able to elicit efficient anti-tumour responses, mediated by CD8+ and NK cells, which resulted in inhibition of the tumour growth, metastases formation and prolonged survival of the animals treated.
The BFS-1 mouse model demonstrated a tendency (p<0.09) for tumor weight reduction after treatment with the peptide (Fig. 7 (f)).
Histopathologically, the mouse model demonstrated accumulation of abnormal lysosomal inclusions in multiple tissues and neuronal cell loss with concomitant astrocyte activation [18], [19].
Experiments in mercury-induced AKI mouse model demonstrated that apoptosis, oxidative stress and toxic renal failure were significantly attenuated by pretreatment with capsids prior to the mercury insult.
Computational modelling of the mouse model demonstrated that passive displacement of embryonic limbs in utero due to movement of the mother and normal littermates would produce greater stimulation of the hindlimbs than the forelimbs providing a possible source of compensation for the reduced stimulation, particularly in the hindlimbs (unpublished data).
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Additionally, studies in the DMD mdx mouse model demonstrate that cellular uptake of a PMO is enhanced by co-administration of a glucose-fructose formulation, resulting in the restoration of higher dystrophin protein levels in the skeletal muscle [97].
The inducible character of our HGF mouse model demonstrates that prenatal development is the specific stage influenced by activation of Met signalling.
The established transgenic mouse model demonstrates that adipose tissue produced hSAA enters the circulation, resulting in elevated plasma levels of hSAA.
In vivo mouse model demonstrates suppressed E. coli and S. pneumoniae clearance following acid aspiration.
Virulence studies in the mouse model demonstrate that, like IUM 96-2828, the strain is significantly less virulent than H99.
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