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Therefore, a mouse model containing activated glial cells with prominent cytoplasmic branching processes and hypertrophied nuclei, namely the soman-intoxicated mouse, was chosen.
We have generated a transgenic mouse model containing in its genome a loxP-STOP inactivated hVEGF-A165 expression cassette, which can be activated by Cre gene transfer in any tissue at any point during life [25].
We describe a mouse model containing a modified Mbd5 gene that severely decreases Mbd5 expression.
Gazit and colleagues [ 68] generated a transgenic mouse model containing the luciferase promoter under control of an osteoblast-specific osteocalcin promoter fragment.
In search of further evidence to identify a tissue-specific role of SIRT1 in the regulation of energy homeostasis, we developed a knockout mouse model containing hepatic deletion of SIRT1 (LKO) [ 17].
The PBOX compounds also induced apoptosis in clinical ex vivo CML patient samples including those resistant to imatinib whereas PBOX-6 reduced tumour load in a CML mouse model containing the T315I Bcr-Abl mutation.
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The level of CD8+ T cell responses in the ELISPOT assay can not directly be compared to the level of CD4+ T cell responses, as this mouse model contains a very low level of CD8+ T cells compared to CD4+ T cells [12].
This digital mouse model contains all the major organs represented in 306,773 tetrahedra.
The Ts1Cje mouse model contained a partial monosomy of MMU12 following partial translocation of MMU16 onto this site.
10 24–26 The B6.Sle1.2.3 (B6.SLE) mouse model contains three genetic loci (Sle1, Sle2 and Sle3) which confer SLE susceptibility.
One mouse model contains a hypomorphic Mdm2 allele, which only expresses approximately 30% of the wild-type Mdm2 allele due to the insertion of a puromycin selection cassette in the Mdm2 locus at intron 6.
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