We believe that mouse models constitute an ideal model system to investigate the origins and consequences of DNA damage in sperm.
Studies of the underlying mechanisms that link premeiotic Ate1 function with normal development using germ line-specific Ate1 knockout mouse models constitute an exciting direction of further research.
Presumably, since the mouse knockout model constitutes a null mutation for the mouse Cox-2 gene and results in a phenotype that is similar to the canine RD model, it is likely that the changes in the promoter region of the canine Cox-2 results in reduced amounts of Cox-2 protein.
The clinical finding of SAN dysfunction in a small subset of diabetic patients and the discrepancies in the experimental findings of heart rate in db/db mice imply that this mouse model may constitute a unique tool for studying the effects of diabetes on SAN function.
Furthermore, because they naturally develop spontaneous cancers, in contrast to mouse models, they constitute an excellent comparative model for cancer [ 27].
The mechanism for the reduced recruitment of inflammatory cells into the brain of Hpa-tg mice was verified with an in vitro BBB model constituted with primary endothelia cells and pericytes [ 29].
This integrated model constitutes a new war-labor paradigm.
The model constitutes two main contributions.
This model constituted the framework for data collection and analysis.
Genetically engineered mouse (GEM) cancer models constitute powerful, alternative methods to assess the carcinogenetic potential of non-genotoxic compounds [ 28].
