An additional mouse model consisting of a double Pank1/Pank2 knockout (Garcia et al., 2012) showed a severe phenotype characterized by hypoglycaemia and hyperketonaemia leading to dysfunctional post-natal development and premature death at 17 days.
To assess how OPN and thrombin-uncleavable OPN affect initiation and growth of primary tumors and metastases, an in vivo mouse model consisting of athymic nude (nu/nu) mice was used.
In the present study, we describe a 10 day mouse model consisting of a single dose of elastase administration to establish severe emphysematous lung disease followed by RV infection that recreates many of the inflammatory features of human RV-induced COPD exacerbation.
This so-called 'stress reactivity' (SR) mouse model consists of three separate breeding lines selected for either high (HR), intermediate (IR), or low (LR) corticosterone increase in response to stressors.
At a high viral dosage, actively proliferating tumour cells were effectively suppressed in two independent subcutaneous xenograft mouse models consisting of human glioma and hepatocellular carcinoma cells.
We therefore developed an ex vivo co-culture model consisting of mouse leukemic pro-B lymphoblasts [ 2] grown with mitotically inactivated mouse embryonic fibroblasts (MEFs).
To study the effects of the compounds on IL-1β- and TNFα-induced cartilage degradation, we used an ex vivo model consisting of mouse fetal metatarsals [ 29, 30].
To improve on this, we have added a number of previously unused features, and built a composite SVM model consisting of three sequentially applied SVMs and applied it to the human and mouse genomes.
The presented mouse SAN cell model consists of a 38 variable coupled stiff nonlinear ODE system.
The membrane currents considered in the mouse SAN cell model consist of INa (INa,1.1 and INa,1.5), ICaL (ICaL,1.2 and ICaL,1.3), ICaT, Ist, If (If,HCN4), IKr, IK1, INaCa, INaK, and other miscellaneous currents (IKs, I sus, Ito, and background currents).
Therefore, the model consisting of Eqs.
