Our results were confirmed in vivo in a tumor xenograft mice model conducted previously.
Consistent with the mouse model, studies conducted in human populations have shown that malaria induced IFN-gamma production is associated with lower infection rates and resistance to re-infection [18] and with reduced risk of clinical malaria [19].
Then, we examined the potential of the nanoparticles as a nasal vaccine adjuvant and protection against lethal influenza infection in a mouse model and conducted mechanistic analyses.
To confirm if the mechanism of action by ICG-001 is preserved in the mouse model, we conducted immunopercipitation (IP) experiments with β-CATENIN in the absence or presence of the inhibitor and immunoblotted for CBP (Fig 3F).
In this study, we developed knockin mouse models and conducted intravital in vivo live-imaging and pulse-labeling studies of GFRα1+ spermatogonia at a single-cell resolution.
In vivo studies using a xenograft mouse model was subsequently conducted to determine whether oral administration of FA + ASP c-SLN combinations could suppress the growth of pancreatic tumor.
Up to now, one clinical human study and one preclinical mouse model study have been conducted with 177Lu-DOTA-JR11 (OPS2012][12] 12].
A co-clinical study in a mouse model of PDA was conducted to differentiate between the effects of nab-paclitaxel and gemcitabine.
Intrigued by the rapid improvement in his AA, we evaluated the effect of baricitinib in a mouse model of AA and conducted mechanistic studies to understand the action of baricitinib.
Detailed studies following the development of schistosome-specific cellular responses over a period of time have been conducted in the mouse model, but such studies have yet to be conducted in human schistosomiasis (see [ 14] for review).
