We summarized the complex phenotypes of intestinal crypt cells in reported mouse models concerning the cross-talk between the Hippo and Wnt pathways.
In another study concerning mouse model of human ovarian endometrioid adenocarcinoma [ 23], the authors performed IHC and sequence analysis, in parallel, on some genes implicated in the pathology.
Using these mouse models, much knowledge concerning the pathogenesis of the disease and therapeutic intervention has been gained, eg, origins of endothelial and smooth muscle cells in lesions of transplant and vein graft atherosclerosis.
CAC has applied for patent protection concerning a mouse model of AD discussed in the manuscript.
However, the utility of the ob/ob mouse model is limited by concerns with the development of liver fibrosis.
The previously generated HCV transgenic (HCV-Tg) mouse models produced inconsistent results concerning the role of HCV proteins in HCC development.
The conditional HSP60 mouse model is useful for studying crucial biological questions concerning HSP60.
These original biocomposites were fully characterized and in vivo biological assays concerning the AD treatment were performed using a mouse model induced by 2,4-dinitrochlorobenzene (DNCB).
Concerning interactions among leptin and 5HT, a previous mouse model study reported that peripheral leptin levels were reduced by 5HT, and 5HT exerted a direct effect on adipocytes and regulated leptin release from adipocytes [ 15].
Another CTG formulation initially failed FDA approval in June 2005 because of concerns of dermal carcinogenicity in a single mouse model (Velac® Gel, Connetics Corporation, Palo Alto, CA).
