Sentence examples for mouse model combines from inspiring English sources

The rd/rd cl mouse model combines a homozygous retinal degeneration (rd/rd or Pde6b rd1 ) mutation with an attenuated diphtheria toxin-human red cone promoter transgene (cl) to provide a complete ablation of rod and cone photoreceptors by 80 days old (Lucas et al., 1999).

In a SQ20B tumor-bearing mouse model, combining the Gd-based nanoparticles with 10 Gy irradiation led to significant delay of tumor growth (Miladi et al. 2015).

In the future, the pneumonectomy mouse model combined with genetically modified mouse lines, lineage tracing approaches, and single-cell transcriptomic analyses will be powerful tools to shed new lights on the regenerative aspects associated with de novo alveologenesis.

Thus, we generated the first tricistronic podocyte mouse model combining enhanced Cre recombinase efficiency and fluorescent labeling in podocytes without the need for additional matings with conventional reporter mouse lines.

Here we designed a novel podocyte-specific tricistronic Cre mouse model combining codon improved Cre expression and fluorescent cell labeling with mTomato under the control of the endogenous Nphs2 promoter using viral T2A-peptides.

This MDA-MB-435s/tk-luc human breast carcinoma-bearing mouse model combined with multimodalities of molecular imaging may facilitate studies on the molecular mechanisms of cancer invasion and metastasis.

Interestingly, in another mouse model combining genetic ablation of rods with the disabling of cone phototransduction (Rho−/−, Cnga3−/−) there is no detectable ERG response [17].

Hence, LDLR-/ mice seem to be a valuable basis to establish an atherosclerotic mouse model combined with high-fat diet-induced obesity and insulin resistance.

The mechanically loaded PTOA mouse model combined with IVIS scanning provides a means to monitor drug effects using this treatment method longitudinally without animal sacrifice [ 28].

In this paper, we describe the creation of a novel mouse model combining the key features of obesity, diabetes, and AD.

Furthermore, in a neuroblastoma xenograft mouse model, combined treatment of topotecan and bortezomib significantly delayed tumor formation compared to single-drug treatments.