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This MDA-MB-435s/tk-luc human breast carcinoma-bearing mouse model combined with multimodalities of molecular imaging may facilitate studies on the molecular mechanisms of cancer invasion and metastasis.
In the future, the pneumonectomy mouse model combined with genetically modified mouse lines, lineage tracing approaches, and single-cell transcriptomic analyses will be powerful tools to shed new lights on the regenerative aspects associated with de novo alveologenesis.
Hence, LDLR-/ mice seem to be a valuable basis to establish an atherosclerotic mouse model combined with high-fat diet-induced obesity and insulin resistance.
The mechanically loaded PTOA mouse model combined with IVIS scanning provides a means to monitor drug effects using this treatment method longitudinally without animal sacrifice [ 28].
Furthermore, in a neuroblastoma xenograft mouse model, combined treatment of topotecan and bortezomib significantly delayed tumor formation compared to single-drug treatments.
These results suggest that our mouse model combined with H. pylori infection and high-salt diet is useful for gene expression profiling in gastric carcinogenesis, providing evidence that CD177 is a novel prognostic factor for stomach cancer.
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Thus, we generated the first tricistronic podocyte mouse model combining enhanced Cre recombinase efficiency and fluorescent labeling in podocytes without the need for additional matings with conventional reporter mouse lines.
Here we designed a novel podocyte-specific tricistronic Cre mouse model combining codon improved Cre expression and fluorescent cell labeling with mTomato under the control of the endogenous Nphs2 promoter using viral T2A-peptides.
In a SQ20B tumor-bearing mouse model, combining the Gd-based nanoparticles with 10 Gy irradiation led to significant delay of tumor growth (Miladi et al. 2015).
In this study, we describe a mouse model combining type 1 diabetes with activation of the renin-angiotensin system (RAS), which develops robust kidney disease with features resembling human DN: heavy albuminuria, hypertension, and glomerulosclerosis.
Interestingly, in another mouse model combining genetic ablation of rods with the disabling of cone phototransduction (Rho−/−, Cnga3−/−) there is no detectable ERG response [17].
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Justyna Jupowicz-Kozak
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