Sentence examples for mouse model characterized from inspiring English sources

Using a transgenic mouse model characterized by CNS hypermyelination, we show that larger myelin content results in greater severity of experimental autoimmune encephalomyelitis attributable to an increased number of microglia within the hypermyelinated brain.

The humanized mouse model characterized in this paper may facilitate the study and understanding of the functions of the human CYP2C enzymes.

To assess the potential role of transforming growth factor beta (TGF-β) overactivity in driving these cardiovascular abnormalities, we studied a novel transgenic mouse model characterized by ligand-dependent activation of TGF-β signaling in fibroblasts.

Samuele De Minicis (Università Politecnica delle Marche, Ancona, Italy) demonstrated the role of fibrosis as a cofactor in a new mouse model characterized by the evolution of NASH to liver cancer.

However, these mechanisms have been proposed to explain the recent observation that a pan-PPAR agonist, bezafibrate, was able to correct the COX defect, ameliorate motor impairment, and prolong life span, in MLC1F-Cox10 −/−, a mouse model characterized by muscle-selective ablation of Cox10, a heme a biosynthetic enzyme.

In the LDL-R−/− model, we studied the effect of Dunaliella on early atherogenesis; therefore, in the present study we aimed to investigate the effect of Dunaliella on the progression of established atherosclerosis, using apoE−/− mouse model characterized with advanced atherosclerotic lesions.

The bioluminescent mouse models characterized here could serve as important tools for biomedical research.

Among AD animal models, TgCRND8 mice showed a more extensive spectrum of synaptic alterations compared to other AD mouse models, characterized by mutations only in the APP gene (APP23 and Tg2576 mice).

We tested this hypothesis on three recombinant mouse models characterized by defective cytochrome c-oxidase (COX) activity: a knockout (KO) mouse for Surf1, a knockout/knockin mouse for Sco2, and a muscle-restricted KO mouse for Cox15.

Transgenic mouse models characterized by conditional expression of the simian virus 40 T antigen oncogene in postmitotic neurons clearly presented a neurodegenerative phenotype, consequence of forced cell cycle activation [ 32].

Our results are concordant with very recent works reporting beneficial effects of NAD+ precursors in mouse models characterized by reduced NAD+/NADH ratio, such as aging (Gomes et al., 2013) or complex I deficiency (Karamanlidis et al., 2013).