Sentence examples for mouse model characterised from inspiring English sources

In the mouse model characterised in this study, the regulation of this latter process has been altered by the introduction of a single nucleotide missense mutation in the endogenous Guca1a gene using gene targeting.

The strongest experimental evidence aimed at defining cellular targets for inflammation in SpA was found in the TNFΔARE mouse model, characterised by a 69-base pair deletion of the tumour necrosis factor (TNF) AU-rich elements (AREs) from the mouse genome.

This mouse model is characterised by several DS-related neuropathological features including cognitive impairment and reduced hippocampal LTP.

We have used MDCKII cells over-expressing ABCB1, ABCC1, ABCC2 and ABCG2, alongside knockout mouse models to characterise actinomycin D transport and its impact on pharmacokinetics.

The validity of autophagy modulation as a therapeutic strategy has been shown in a mouse model of Ulrich myopathy characterised by defective autophagy and accumulation of dysfunctional organelles.

We are now developing mouse model assays to further characterise the role of the CCL20 CCR6 axis in Treg cell homing in vivo.

To characterise our mouse model, we first analysed the effect of OVX on intact bone and fracture healing.

Results In this study, the authors generated and characterised a knockout mouse model for Rab18.

We have now developed and characterised a new syngeneic mouse model of metastatic breast cancer in C57BL/6 mice.

By characterising the transgenic arcAβ mouse model of AD which presents a strong vascular pathology at early, mid and late disease stages we investigated what processes could possibly instigate the vascular and metabolic impairments early on in the disease and which mechanisms aggravate the vascular pathology at later stages in this AD mouse model.

Here, we have used a mouse model expressing a mutated form of BRAF, known as V600EBRAF, to characterise cells within the stroma and to investigate novel mechanisms involved in the recruitment of these cells to the tumour microenvironment.