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This study presents a new coisogenic mouse model carrying a point mutation in Ffar1 with functional consequence.
In the new mouse model carrying HBV cccDNA, injection of sgRNA Cas9 plasmids via rapid tail vein resulted in the low level of cccDNA and HBV protein.
We studied our previously established mouse model carrying a homozygous mutation in the key enzyme of sialic acid biosynthesis, N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
A recently described transgenic mouse model carrying the D4Z4 array of the FSHD allele developed progressive keratitis of unknown etiology resulting in blindness, supporting the possibility of extramuscular inflammation [19].
In a FHM2 KI mouse model carrying the human W887R mutation in the Atp1a2 orthologous gene, in vivo analysis of CSD in heterozygous F Atp1a2 (+/R887) mutants revealed a decreased induction threshold and an increased velocity of propagation.
Recently a mouse model carrying disruption of Lias, gene encoding lipoic acid synthase, has been described [31].
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The YAC128 mouse model carries 128 CAG repeats and is known to develop several HD-like symptoms.
This transgenic mouse model carries M233T/L235P knocked-in mutations in presenilin-1 and overexpresses mutated human β-amyloid (Aβ) precursor protein.
This mouse model carries a copy of the human SMN2 gene and has previously been described (42).
However, because this mouse model carries three transgenes, it was not clear whether all or one mutation contributed to the loss of GABAergic interneurons.
This shows that mouse models carrying the Cre transgene alone can have significant behavioural phenotypes.
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