Sentence examples for mouse model but from inspiring English sources

This approach has worked successfully in a genetically engineered mouse model but failed in humans, paradoxically increasing mortality in the treatment arm.

"It looks promising in the mouse model but in recent years, these types of experiments in mice have not translated well into humans".

We have demonstrated the differentiation potential of SOX9+ BCs in mouse model, but the exact fate of transplanted SOX9+ BCs in human lung remains to be proven with future development of non-invasive cell tracking techniques.

The B. melitensis B115 rough strain has demonstrated its efficacy against B. melitensis virulent strains in the mouse model, but there is a lack of information regarding its potential use in small ruminants for brucellosis control.

The local pulsatile PTH delivery (daily pulse for 21 days) not only promoted the regeneration of a critical-sized bone defect with negligible systemic side effects in a mouse model, but also advantageously achieved higher quality regenerated bone than the standard systemic PTH injection.

Previously, we developed SIRT2 inhibitors based on the 3- N-arylsulfamoyl benzamide scaffold, including3- N-arylsulfamoyl benzamidel)-N-(4-bromophenyl)benzamide(C2–8, 1a), which demonstrated neuroprotective effects in a Huntington's mouse model, but had low potency of SIRT2 inhibition.

The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials.

Rajendran hopes Matters can also help level the playing field for researchers in poorer areas, who may lack resources such as antibodies and mouse models, "but can still make good observations".

ARM-relevant choroidal neovascularization and cell loss have been productively studied in mouse models but bona fide drusen have been a more elusive target [83], [84].

The microarray-based analytical approach we have implemented does not replace conventional validation criteria for psoriasis mouse models, but extends these criteria by providing a quantitative "yardstick" that can be used to clearly judge progress towards more realistic mouse phenotypes.

Toll-like receptors (TLRs) play a critical role in initiating the innate immune response to many pathogens in mouse models, but little is known about their role in human infections.