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In the Escherichia coli-infected mouse model, all of hybrid dimer analogues had significantly lower degree of bacterial load than the untreated control group when injected once i.p. at 5 mg/kg.
In the mouse model, all experiments were repeated at least three times.
Unlike our study, done in a mouse model, all these studies were done in cell culture.
In this mouse model all P450 isoforms involved in the hepatic metabolism of PCBs are inactivated or inhibited because CPR, the required electron donor of all microsomal P450 enzymes, is not expressed in the liver.
For orotic aciduria, the fluxes of 18 reactions in the B. thetaiotaomicron model and 11 reactions in the mouse model, all involved in nucleotide metabolism and nucleoside transport, increased more than 3-fold compared with the wildtype iexGF MM_ BΘ (Table S7a ).
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In the in vivo NOD/SCID xenograft mouse model, ALL-3 is highly responsive to 4 weeks of treatment with single agent dexamethasone, with rapid clearance of leukemic blasts from the peripheral blood and recurrence of leukemia delayed by 63.4 days compared to vehicle-treated controls [ 20].
In particular, of the 46 genes with strong association signals in CAD GWASs that were studied in mouse models, all but one exhibited consistent effects on atherosclerosis-related phenotypes.
These three mouse models all share a pattern of peripheral degeneration with Optn E50K mice.
We used three mouse models all of which have an LMP2A transgene insertion.
The recent knock-in mouse models all demonstrated a myeloproliferative phenotype: all three models expressing the mouse heterozygous JAK2V617F exhibited a PV-like phenotype, whereas the model expressing the human JAK2V617F exhibited an ET-like phenotype.
To address these questions, we have generated a mouse model completely lacking all POMC- and AgRP-derived peptides.
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