Sentence examples for mouse model achieving from inspiring English sources

22 Similarly in our mouse model achieving temperatures between 36.5 and 37.5 °C using dry-cold CO2 for insufflation was difficult requiring continuous intervention with a heat lamp.

In addition, inhibition of TGF-β activity and/or expression in mouse models, achieved using neutralizing antibodies or targeted homologous gene disruption or expression of dominant negative forms of receptors, results in accelerated lesion development (in ApoE−/− mice) and an elevated inflammatory response [6,8,9].

Additionally, no PWS mouse model has achieved a disease phenotype identical to that seen in human PWS patients, which suggests that there are species-specific differences that prevent mice from exhibiting the full human PWS phenotype [ 44].

Presently available mouse models can achieve a high degree of predictive validity for positive outcomes of experimental therapies, but they have been less successful in identifying potential adverse outcomes that can occur in human trials.

Herein we aimed at determining the impact of MS on redox/inflammatory status and potential consequences in the lung using a previously developed mouse model of MS. To achieve this goal, 6 week-old male C57BL / 6J mice were fed for 16 weeks with a low fat- (LFD) or a high fat-diet (HFD, chicken fat) and water supplemented with 10% fructose (F).

The local pulsatile PTH delivery (daily pulse for 21 days) not only promoted the regeneration of a critical-sized bone defect with negligible systemic side effects in a mouse model, but also advantageously achieved higher quality regenerated bone than the standard systemic PTH injection.

Robust phenotypic correction of diseases in mouse models has been achieved paving the way toward the first clinical trials.

In the R6/2 mouse model, however, doses required to achieve similar concentrations in the brain were toxic, therefore lower doses were used (1 and 5 mg/ml in the drinking water) for assessment, which resulted in a concentration of 12.2 µM of minocycline in the R6/2 brain after 5 days of treatment, very similar to the results in our study.

A reproducible mouse model for human neuroblastoma can be achieved typically by subcutaneous (s.c).

Validation of the targeted approach with fluorescence endoscopy was achieved using a mouse model that spontaneously develops adenomas in the distal colon.

In vivo neutralisation was achieved in a mouse model of oral toxin challenge with engineered lactobacilli expressing the neutralising scFv with an APF anchoring domain.