In humans, the larger-sized anterior horn compared with mice may allow greater cellular heterogeneity and greater noise.
The detection of lipocalin 2 in sera from infected mice may allow discrimination when CSF was not collected or lumber puncture was not feasible.
Alternatively, the low levels of activated TGF-β in the sera of A/HK/156/97-infected mice may allow the viruses to replicate and spread unchecked in the respiratory tracts of the mice, causing more severe disease.
Since breast tumors form with predictable rapid kinetics in this model, Wnt-1 TG, Pten+/- mice may allow the testing of molecular-based therapies of potential utility in human tumors showing PTEN loss/mutation.
The development of these Glud1-overexpressing mice may allow for the exploration of key molecular events produced by chronic exposure of neurons to moderate, transient increases in glutamate release, a process hypothesized to occur in neurodegenerative disorders.
The use of conditional knockouts in mice may allow researchers to overcome this problem and test the role of genes identified thus far in high-throughput experiments in a more specific fashion.
Strong and homogeneous β-catenin activation probably leads to Atoh1 destabilisation in the presence of a conditional homozygous deletion of Apc, whereas the heterogeneous β-catenin activation in ApcMin mice may allow Notch inhibition by maintaining Atoh1 levels above a threshold sufficient to induce goblet differentiation, in a subset of cells.
Thus, the study of oligomeric forms of ADan in Tg-FDD mice may allow us to determine the exact roles of intracellular and extracellular ADan peptides in neuronal toxicity and to investigate whether similar mechanisms of toxicity exist between FDD and AD in vivo.
Construction of such mouse "avatars" may allow analyzing functionally patient-specific differences with respect to susceptibility to infection, disease progression and responses to treatment.
Objectives: The understanding of the role of iron metabolism during M. avium infections in mouse models may allow the design of new therapies based on the manipulation of iron stores.
